The methanolic extract of herbal formulations were used to test their antidiabetic activity in Streptozotocin induced diabetic mice.  Utrica dioica was used as single drug while one marketed polyherbal formulation “jameda churna†was also included for the comparative study.   Diabetes was induced in albino mice by single i.p. injection of 50 mg/kg body weight of STZ and were given 200 mg/kg body weight of three different herbal formulation orally. All the formulations have shown potential in their role to reduce the blood glucose level. Polyherbal formulaion, which was rich in alkaloids, tanins and terpenoids, showed the higher activity on in-vitro and in-vivo than tri-herbal and single herbal formulations.