Background: Oorithal thaamarai chooranam is indicated for diabetic patients, it has been screened for toxic effects according to OECD guidelines. The acute toxicity study of Oorithal thaamarai chooranam (OTC) was administered orally in single dose of 5,50,300,1000 and 2000 mg/kg of body weight to the rats. The sub-acute toxicity studies was carried in different doses of Oorithal thaamarai chooranam (OTC)(5, 50, 300, 1000 and 2000mg/kg of body weight) were administered orally to the rats once daily for 28 days. Animals were observed for physiological and behavioural responses, mortality, food and water intake and body weight changes. All the animals were sacrificed on 29th day and changes were noted. No mortality observed up to 2000mg/kg body weight of Oorithal thaamarai chooranam(OTC).. Daily administration of Oorithal thaamarai chooranam (OTC) did not result in any changes in body weight,behaviour and histology of different organs. According to these results Oorithal thaamarai chooranam (OTC) could be concluded as no observed adverse effect level (NOAEL). It also showed the safety of the drug which provided its utility in long time administration without any harm to the human being. Aim:To carried out the acute and sub-acute toxicity evaluation of hydro alcoholic extract of Oorithalthaamarai chooranam (OTC) in Wistar albino rats.
Study design: Observational in-vivo study Place and duration of study: Animal house,Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Srivilliputtur, Tamilnadu.
Materials and methods: Dried parts of Oorithal thaamari whole plant and it was dried under sunshade and then grinded in to fine powder and used for further studies.
Results: It is proved from this evaluation that the herbal siddha drug Oorithal thaamari plant has no adverse effect, mortality and morbidity in
wistar rats.