‘Sharira Guna’ term is first time used by Acharya Gangadhar in respect of the human body to explain its functions and ‘Swaroop’. Yet ‘Sharira Guna’ and ‘Gurvadi Guna’ are same in name and number but there is difference in working because of  the human body is ‘Chetan Dravya’ while rest is ‘Achetan Dravya’ i.e. drug or food. In Ayurveda, Physiology is described in term of ‘Sharira Guna’. ‘Guna of Vata, Pitta and Kapha’ create difference in ‘Prakriti’ of individuals so that every individual has its specific ‘Prakriti’. On the account of ‘Guna’, more than millions of combinations of ‘Dosha’ are possible. This is how Ayurveda can explain the subtle differences between individuals on the basis of ‘Guna’. It is important for each one of us to know our ‘Sharira Guna’ which makes our ‘Prakriti’ in term of ‘Dosha’. ‘Sharira Guna’ can influence the physiological and psychological behaviour of the person. This is need of hour to explore various concepts of Ayurvedic Physiology in terms of ‘Sharira Guna’ with its utility.