Introduction: The objective of this study was to determine the epidemiological, anatomo-clinical and therapeutic aspects of precancerous and cancerous lesions of the cervix in Bamako. Materials and methods: This was a descriptive and analytical cross-sectional study of a prospective nature carried out at the Reference Health Centres (CSRef) of Communes IV, V, the University Hospital Centre (CHU) of Gabriel Touré and the University Hospital of Point G in Bamako.  It took place from January to December 2012. The data was collected on an individual sheet from the International Agency for Research on Cancer (IARC), entered and analyzed using SPSS 10.0 software. Results: The average age of women was 39.42 years. They were between 37-46 years of age in 29.4% of cases. The IVA test was positive in 12.3% versus 13.9% for the IVL test on the 2027 women screened. Suspected cases of cervical cancer were 82 cases (4%) for each of the two observations. Of the 366 (18.1%) biopsies performed, LIEBG (intra cervical neoplasia (CINI)) was 24.31%; LIEHG was 18% (CIN2-12%; CIN3-6%); invasive cancer was 26.6% (squamous cell carcinoma: 25%; adenocarcinoma: 1.6%). We found a predominance of low-grade dysplasia in the 27-36 age groups with 31.83%, high-grade dysplasia in the 37-46 age groups with 22.44% and invasive cancer in the 47-56 age group with 40.78%. The nulligestes and paucigestes were 71.63% and 18.89% respectively. Of the 201 positive polygamists, invasive cancer was 30.84% versus 20.39% of low-grade dysplasias and 17.91% of high-grade dysplasias.  In the 136 patients using a contraceptive method, we found invasive cancer in 13.97% compared to 28.67% of low-grade dysplasias and 19.85% of high-grade dysplasias RAD was most often the therapeutic alternative in 25.2%. After 1 year of follow-up, out of the 242 patients treated, we obtained 17% spontaneous regression, 22.3% complete healing; 6.6% in the process of healing; 12.8% of deaths; 15% of cases lost. Conclusion: Visual inspection methods are simple tests that effectively detect precancerous and cancerous lesions of the cervix. Management of precancerous lesions is easy, but if it is invasive cancer, the difficulties of treatment are related to the clinical stage and the lack of the technical plateau.