Polymorphisms That Affect Propofol Metabolism and Their Clinical Effects
The purpose of this study was to determine the polymorphisms of UGT1A9 and CYP2B6 the effects of these polymorphisms on propofol consumptions and hemodynamic datas and recovery times.This study included 100 pediatric patients (Group I–II; 2–8 years of age), 100 young-median age adults (Group III–IV; 18–60years of age), and 100 elderly patients (Group V–VI; 60years of age and older). Hemodynamic situations, propofol consumption and recovery timesof the patients were recorded. The genotypes UGT1A9 (rs72551330, rs17868320, and rs6714486) and CYP2B6 (rs3745274, rs2279343) were determined by real-time PCR.A remarkable decrease (p=0.043) in heart rate (HR) and blood pressure (BP) was observed following induction in the female children with the polymorphism UGT1A9 (rs72551330). The HR dropped significantly (p=0.044) following induction in the male pediatric group with the polymorphism CYP2B6 (rs3745274). A significant decrease (p=0.004) in BP was observed only in elderly women with the CYP2B6 (rs2279343) polymorphism. Propofol consumption was significantly low in female children. Recovery periods were the same in all groups. Hemodynamic changes were mostly observed in pediatric patients. Propofol consumption was significantly low in female children. Recovery times were similar.