Background: Polycystic ovary syndrome is a serious public health concern through
its symptomology, complications and comorbidities. Many researcher reports a
statistically significant positive correlation between decrease bone mineral density
and polycystic ovary syndrome as various features of this disorder may have an
influence on bone metabolism.
Aim of study: To evaluate bone mineral density in women suffering from polycystic
ovary syndrome and determine the associations between Bone mineral density and
insulin resistance, hyperandrogenemia, Body mass index, and sex hormones.
Study design: A cross sectional study.
Setting: Department of Obstetrics and Gynecology at Baghdad Teaching Hospital /
Medical city.
Patients and Methods: During a period of seven months that was conducted from
April till November 2018. It included 30 women suffering from polycystic ovarian
syndrome attended the outpatient clinic of the hospital seeking for management.
Patients with Cushing`s syndrome, androgen producing adrenal tumors, congenital
adrenal hyperplasia (CAH), thyroid disease, hyperprolactinemia, current use of
contraceptive pills in the last six months, anti-diabetic treatment, and patients on
restrictive diet were excluded from this study. Serum concentrations of follicle
stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), 17 β-
estradiol (E2), testosterone dehydroepiandrosterone sulfate (DHEAS), thyroid
stimulating hormone (TSH), free thyroxin (fT4), fasting insulin and fasting glucose
were determined using electrochemiluminescence immunoassay. Level of serum
calcium, 25- hydroxy vitamin D was measured as it considered the best indicator of
vitamin D level which reflects the stored vitamin D level. Bone mineral density
values also were measured by Dual Energy X-Ray Absorptiometry scan (DEXA).
Results: The highest proportion of study patients showed low Bone mineral density
level (73.3%). The highest prevalence of low level of bone mineral density was found
significantly (P < 0.05) in patients with normal Body mass index , high insulin
resistance, low estrogen level, low vitamin D level, and low serum calcium level
(90%, 82.6%, 90%, 100%, and 100% respectively).
Conclusion: Bone mineral density decrease in a women with polycystic ovary
syndrome due to low estrogen level, VIT D3 deficiency and insulin resistance