Neisseria meningitidis _ is an extremely virulent bacterium that is
associated with worsening of clinical cases related to disseminate intravascular coagulation, which together with septicemia will lead to a cascade of pathophysiological events. The objectives of the study emerge from the perspective of elucidating the main parameters linked to the occurrences of the disease/bacteria and with this, based on methodological processes capable of evaluating the subject, based on bibliographic, explanatory, descriptive and documentary mapping, with articles chosen in the time period from 2014 to 2021 in the databases: Scientific Electronic Library Online (SCIELO), National Library of Medicine (PUBMED), and Caribbean Health Sciences (LILACS), to critically and inclusively cover the entire context of literature, from selective, thematic, and conceptual research to the study chosen. Results show that the disease brings severe conditions to humans, in order to detect disseminated intravascular coagulation it is necessary to examine biochemical, hematological and microbiological markers, discussions point to several methods of identification and characterization based on DNA, even so, it is still limited studies against Neisseria meningitidis , especially when the DIC reaction stands out in the pathology, making it essential to discover more effective and assertive treatments and medications for case resolutions. It can be concluded that Neisseria meningitis affects a large part of the population, and presents high mortality when associated with DIC, requiring a clear and concise diagnosis for the resolution of clinical cases.