The aim of the present study was investigate antibacterial activity of the different milk products.  The commercially prepared milk products with probiotic organisms such as three groups of milk products. The first group was comprised of a fermented skimmed milk product, Yakult Drink. The second was made-up of yogurt products, Nestle yogurt and Ski D’Lite. The last group included powdered infant milk supplements, Neslac and Gain. According to the product information, the fermented skimmed milk product contains Lactobacillus casei; the yogurt has Streptococcus Spp, Lactobacillus Spp and Bifidobacterium Spp., while the powdered infant’s milk is enriched with Streptococcus Spp and Bifidobacterium Spp. The antimicrobial activity against microbial isolates comprised of pathogenic Gram negative bacteria Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa. Gram positive bacteria Staphylococcus aureus and yeast, Candida albicans